Inherited Defects in Immunity

Modeling Autoimmunity

Type-1 diabetes and lupus arise from genetics, and environmental exposures. We model the effect of genetic variants on immune cell development, signaling and response to environmental exposures like infection. The goal of these studies is to identify new treatments for autoimmune disease based on patient genetics.

Primary Immunodeficiency

Primary immunodeficiencies comprise a suite of rare genetic disorders that result in defects in a component of the immune system. We are focused on understanding the biochemical and cellular mechanisms by which genetic variants cause immunodeficiency in an effort to improve their diagnoses and treatment.

Center for Immunity and Immunotherapies

For questions or inquiries,
email: ciitadmin@seattlechildrens.org.

Physical Address

1920 Terry Ave.
Seattle, WA 98101

Mailing Address

M/S CURE 6/7
PO Box 5371
Seattle, WA 98145-5005

Seattle Children’s complies with applicable federal and other civil rights laws and does not discriminate, exclude people or treat them differently based on race, color, religion (creed), sex, gender identity or expression, sexual orientation, national origin (ancestry), age, disability, or any other status protected by applicable federal, state or local law. Financial assistance for medically necessary services is based on family income and hospital resources and is provided to children under age 21 whose primary residence is in Washington, Alaska, Montana or Idaho.